Rajni Fertility Centre
What is IVF?

IVF (In Vitro Fertilisation) is a procedure, used to overcome a range of fertility issues, by which an egg and sperm are joined together outside the body, in a specialised laboratory. The fertilised egg (embryo) is allowed to grow in a protected environment for some days before being transferred into the woman's uterus increasing the chance that a pregnancy will occur.

In Vitro Fertilisation (IVF) can be used to overcome a range of fertility issues and for many couples, gives them the best chance of having a baby.IVF Treatment


Intrauterine Insemination (IUI), also known as artificial insemination, may be an option for couples if the woman’s fallopian tubes are patent (no blockage) and the man’s sperm count is adequate. Although the success rate per treatment is lower with IUI than IVF-ICSI, IVF rajni Fertility Center has a high rate of success in all of our assisted reproduction treatments.


In an IUI cycle, a semen sample is taken, and the concentrated sperm is placed into the uterus near the time of ovulation. Medication may be prescribed to stimulate the ovaries.

  • Day 3 of the menstrual cycle:

    An assessment is made through an ultrasound and blood test. Medication may be prescribed to stimulate the growth of multiple follicles in the ovaries. These follicles will hopefully develop to have mature eggs.

  • Day 8, 9 or 10:

    Endometrial lining and follicle size are assessed through ultrasound to determine the date of the next visit.

  • Day 11, 12 or 13:

    A trigger shot may be given to induce maturation of the egg within a scheduled time frame, and the IUI is timed accordingly.

  • Day 13, 14 or 15:

    36 to 40 hours after the trigger shot, the IUI is carried out. A semen sample is provided and sperm is prepared, concentrated (washed) and placed in the uterus using a thin catheter. *The above dates are an approximation of an average cycle.

Should I be considering IUI? Do I have any other options?

IUI is commonly used when fertility issues are related to unexplained infertility, mild endometriosis, low sperm count, ejaculation issues or decreased sperm mobility. IVF is recommended for most causes of infertility, including women over 35 years old, women with low egg supply, men with very low sperm count, men with very low sperm motility and abnormal morphology, women with tubal issues, and women with fertility disorders like endometriosis and polycystic ovary syndrome (PCOS).

For patients younger than 38 years old with no previous fertility treatment, the suggested route is to proceed with two to three cycles of artificial insemination, followed by IVF. For some patients, starting with IVF would be a better option as time can be a critical factor in fertility.


In Vitro Fertilization (IVF) is the process of collecting eggs from a woman and sperm from a man, and fertilizing them in the embryology laboratory. In order to increase chances of fertilization, a single sperm is injected into each of the retrieved eggs using a micropipette in a process called Intra-Cytoplasmic Sperm Injection (ICSI).

What are the benefits of IVF-ICSI?

IVF-ICSI has been shown to improve the fertilization rate in a number of cases. It may be especially helpful for people suffering from:

  • • Poor Ovarian Reserve
  • • PCOD
  • • Previous failed fertilization
  • • Low sperm count
  • • Poor sperm motility
  • • High amount of abnormal sperm
  • • Retrograde ejaculation
  • • Vasectomy
  • • Immunological factors
  • • Other conditions that prevent fertilization of the egg

What are the steps and duration of an IVF-ICSI cycle?

During the initial consultation, one of IVF Michigan’s infertility specialists will take a full medical history and may perform a checkup that includes an ultrasound scan and blood tests to check hormonal levels. Based on the medical history and clinical exams, a personalized treatment plan is constructed. If the IVF specialist suspects that infertility may be attributed to a male factor, a semen analysis will be conducted before treatment, and the protocol will be altered as necessary.

Steps of IVF-ICSI (duration 21-25 days)

  • Ovarian Stimulation (7 to 10 days):

    On day 2 or 3 of the menstrual cycle, medication is prescribed to stimulate the growth of multiple follicles in the ovaries. During this time, follicular growth is monitored through ultrasound as they develop into eggs, and hormone levels are tracked through blood tests. Medication protocols are changed as needed. 36 hours before the scheduled egg retrieval, a trigger shot(s) is given to induce maturation of the eggs within a scheduled timeframe.

  • Egg Retrieval (OPU):

    Eggs are retrieved using a thin ultrasound-guided needle during a short procedure under sedation. The number of eggs retrieved depends on the body’s response to the medication.

  • Sperm Collection and ICSI:

    On the day of egg retrieval, a semen sample is taken to fertilize the retrieved eggs. To increase chances of fertilization, a single sperm is injected into each egg using a micropipette

  • Genetic Testing (optional):

    If Pre-Implantation Genetic Testing (PGT) or Pre-Implantation Genetic Testing Diagnosis (PGT-M) will be completed to help prevent passing on a hereditary disease, 3 to 5 days after the egg retrieval, a biopsy is taken of each embryo. The embryos will then be transferred to the uterus during a future cycle.

  • Embryo Transfer:

    Embryo transfer is a minor procedure that does not require sedation. Following the procedure, hormone levels are tracked through blood test to confirm pregnancy. Any embryos that are not transferred may be frozen and used in a future cycle.

  • Embryo Freezing:

    Any Embryos that are not transferred may be frozen or all embryos may be frozen if endometrium is not sufficient.